Autoimmune/inflammatory Syndrome Induced by Adjuvants. Vertaald: Autoimmuun/ontstekingssyndroom gestimuleerd door hulpstoffen. Bij ASIA is silicone de hulpstof (adjuvans) die het immuunsysteem activeert.

Vanwege de chronische prikkeling door het siliconen borstimplantaat, in combinatie met een genetische gevoeligheid, kan een auto-immuunreactie ontstaan met typerende klachten. (zie hieronder bij criteria)

Belangrijkste criteria ASIA  >> 

• Blootstelling aan externe prikkels  door infecties, vaccinatie, siliconen (adjuvant)

• Verschijnselen van een van de klinische verschijnselen:  

• Spierpijn, myositis (spierontsteking) of spierzwakte                 

• Gewrichtspijn of gewrichtsontsteking

•  Chronische vermoeidheid, slecht slapen of slaapstoornis

• Neurologische verschijnselen die geassocieerd worden met demyelinisatie

• Cognitieve veranderingen, geheugenverlies, vergeetachtigheid

• Koorts, droge mond

• Door het verwijderen van het hulpmiddel van siliconen, treedt  verbetering op

• Typische biopsie van de betrokken organen

Minder belangrijke criteria

• Verschijnen van auto-antistoffen gericht tegen de verwachte adjuvantia

• Andere klinische verschijnselen (zoals prikkelbare darm syndroom)

• Specifieke HLA (Humaan Leukocyten Antigen) (zoals HLA DRB1, HLA DQB1)

• Inleiding van een auto-immuunziekte (zoals Multiple Sclerose, Systemische Sclerose) >> 

Verder worden genoemd >> 

• Moeheid 

• Malaise 

• Concentratiestoornissen 

• Ochtendstijfheid

• Raynaud`s fenomeen

• Kortademigheid

• Langdurige koorts

• Terugkerende infecties

• Gewichtsverlies

• Polyneuropathie klachten (Pijn, tintelingen, loopstoornissen enz)

• Oogontstekingen

• Aanwijzingen voor hyper- of hypothyreoïdie (schildklier)

De symptomen lijken erg op die van Fibromyalgie, zoals ernstige vermoeidheid en spierklachten >>

Ook lijken de symptomen op het Syndroom van Sjögren, zoals droge ogen en droge mond >>

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023☆ >> 

Adjuvant-induced autoimmune syndrome triggered by silicone breast implants: systematic review. 2022 >> 

Breast implant illness: scientific eveidence of its existence. 2021 >>

Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture. 2021 >> 

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. 2019 >> 

Autoimmune/Inflammatory Syndrome Induced by Silicone Breast Implant and Risk Factors Associated to Autoimmune Diseases. 2019  >>

Autoimmune/inflammatory syndrome induced by adjuvants due silicone breast implant and rheumatic diseases. 2019 >>

Silicone breast implants and the risk of autoimmune/rheumatic disorders: a real-world analysis. okt 2018 (2 miljoen deelnemers, studie van 20 jaar) 2018 >>

Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld's syndrome): A new flame. 2018 >>

Autoinflammatory/autoimmunity syndrome induced by adjuvants (Shoenfeld's syndrome) in patients after a polypropylene mesh implantation. 2018 >> 

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry. 2017 >>

Destiny rides again: the reappearance of silicone gel-filled breast implant toxicity. 2017 >>

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature. 2016  >>

Autoimmune / inflammotory Syndrome induced by Adjuvants and Sjögren Syndrome (PDF) april 2016 >>

Vaccins and autoimmunity (book) 2015 >>

Severe ASIA syndrome associated with lymph node, thoracic, and pulmonary silicone infiltration following breast implant rupture: experience with four cases. 2015  >> 

Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk? 2015  >>  

Adjuvants and lymphoma risk as part of the ASIA spectrum. 2015   >>  

Long-term inflammatory conditions following silicone exposure: the expanding spectrum of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2014  >>

Silicone implant incompatibility syndrome (SIIS): A frequent cause of ASIA (Shoenfeld’s syndrome) 2012   >> 

ASIA - Autoimmune/inflammatory syndrome induced by adjuvants. 2010 >>  

ASIA: A New Way to Put the Puzzle Together. 2011  >>

ASIA’ - Autoimmune/inflammatory syndrome induced by adjuvants: even and odd. 2011 >>

The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’. >> 

Autoimmune syndrome induced by adjuvants (ASIA) in the Middle East: morphea following silicone implantation. 2012  >>   

Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld's syndrome) 2012  >>  

The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants 2011 >>  In 2015 >> 

Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA). 2012 >> 

'ASIA' - Autoimmune/inflammatory syndrome induced by adjuvants. 2011 >>